RNA BaseCode™ Brings Long-Read Transcript Resolution to Standard Short-Read Sequencing
STOCKHOLM, Sweden – December 15 2025 – Basic Genomics, a company advancing RNA technology to empower next-generation molecular insights, today announced the launch of its RNA BaseCode™ Kit. These innovative kits enable researchers to obtain deeper insight into isoforms, splicing, and transcript complexity, all from standard short-read sequencing platforms. They characterize and quantify RNA isoforms with unprecedented precision and reproducibility, bringing advanced RNA analysis into everyday lab workflow.
“With RNA BaseCode, we overcome the long-standing barrier to scalable, quantitative and accurate RNA isoform profiling which is essential for understanding how RNA and proteins drive biology and disease,” said Gert-Jan Hendriks, CEO of Basic Genomics.
RNA BaseCode introduces a new approach to RNA sequencing that produces highly accurate synthetic long-read data using standard short-read sequencing platforms. The method achieves significantly higher base accuracy than conventional long-read sequencing while requiring nearly 100-fold less RNA input. Applications span from cancer biology to developmental genomics, offering new insights into how transcript diversity contributes to health and disease.
The proprietary RNA BaseCode chemistry and software leverage distinct error patterns introduced during reverse transcription to accurately link short reads originating from the same RNA molecule. By uniting the accuracy and quantitative power of short-read sequencing with a chemistry capable of reconstructing full-length RNA sequences, RNA BaseCode enables scalable and reliable detection of RNA isoforms.
For more details, please have a look at the Basic Genomics preprint (https://doi.org/10.64898/2025.12.09.693136).
“RNA BaseCode combines the strengths of short-read sequencing with the insights gained from sequencing full-length cDNA, all in a kit that relies only on standard laboratory equipment,” said Prof. Rickard Sandberg, co-founder of Basic Genomics. “We are excited to see this technology advancing the study of RNA isoform regulation in human health and disease.”
By providing a straightforward, kit-based workflow that runs on standard laboratory equipment, Basic Genomics is lowering technical barriers and accelerating the adoption of high-resolution RNA profiling. Early customer results are already demonstrating the practical impact of RNA BaseCode data and the importance of resolving RNA isoforms.
Dr. Maki Sakuma, Postdoctoral Researcher at St. Anna Children’s Cancer Research Institute in Vienna, Austria noted: “RNA BaseCode allowed us to quantify isoform switching of lowly expressed genes, a challenge we had previously struggled with. We are excited about the potential of this technology to enable splicing-informed clinical insights in pediatric cancers.”
The launch of RNA BaseCode marks an important milestone in making the interrogation of RNA isoforms and RNA biology more accessible and scalable. In the coming years, Basic Genomics will expand the BaseCode product line with additional solutions designed for single-cell and spatial biology.
About Basic Genomics
Basic Genomics develops technologies that make complex RNA Biology accessible to every lab. Founded by leading scientists from Karolinska Institutet, the company’s mission is to accelerate discovery through reliable easy-to-use tools that reveal the regulatory power of RNA. The company’s BaseCode™ technology platform enables unprecedented accuracy and throughput in the quantitative and qualitative analysis of RNA isoforms, providing new insights into gene expression, cellular function and disease mechanisms. Located in Stockholm, Sweden, Basic Genomics collaborates globally with academic and industry partners to push the boundaries of transcriptomics.
Visit www.basic-genomics.com for more information.